effect of resonant acoustic mixing on pharmaceutical
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effect of resonant acoustic mixing on pharmaceutical.

Effect of resonant acoustic mixing on pharmaceutical ...

Jul 01, 2016  With no reported knowledge of the effect of resonant acoustic mixing on powder blends and finished product properties, the main objective of this study was to investigate the effects of resonant acoustic mixing on the bulk properties of pharmaceutical blends and tablets.

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Effect of resonant acoustic mixing on pharmaceutical ...

Blending in a resonant acoustic mixer (RAM) was shown to be highly effective for low concentrations of cohesive active pharmaceutical ingredients (APIs) and lubricant (Osorio and Muzzio, 2015). However, changes in material properties of the final blend were observed. Those changes, and their effects on tablet characteristics, are discussed in ...

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Effect of resonant acoustic mixing on pharmaceutical ...

The blending performance in a resonant acoustic mixer (RAM) was characterized. The system showed to be highly effective in blending low concentrations of cohesive active pharmaceutical ingredients (APIs) and lubricants. A summary of these results will be described and changes in material properties were observed. Those changes, and their effects on tablet characteristics, were also studied.

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Effect of resonant acoustic mixing on pharmaceutical ...

Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets Osorio, Juan, [email protected], Purdue University, United States; Sowrirajan, Koushik, FDA, United States; Muzzio, Fernando, Rutgers University, United States ABSTRACT The blending performance in a resonant acoustic mixer (RAM) was characterized.

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Effect of resonant acoustic mixing on pharmaceutical ...

Request PDF Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets Blending in a resonant acoustic mixer (RAM) was shown to be highly effective for low concentrations ...

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Evaluation of resonant acoustic mixing performance ...

Jul 01, 2015  In this paper, the goal is to evaluate the mixing performance of a new mixer, a resonant acoustic mixer (RAM), using common pharmaceutical powders. This mixer works on a different principle than those commonly used for pharmaceutical processing, using resonant vibration to induce fast motion and homogenization of powders.

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Effect of resonant acoustic mixing on pharmaceutical ...

The blending performance in a resonant acoustic mixer (RAM) was characterized. The system showed to be highly effective in blending low concentrations of cohesive active pharmaceutical ingredients (APIs) and lubricants. A summary of these results will be described and changes in material properties were observed. Those changes, and their effects on tablet characteristics, were also studied.

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Effect of resonant acoustic mixing on pharmaceutical ...

Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets Osorio, Juan, [email protected], Purdue University, United States; Sowrirajan, Koushik, FDA, United States; Muzzio, Fernando, Rutgers University, United States ABSTRACT The blending performance in a resonant acoustic mixer (RAM) was characterized.

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What is ResonantAcoustic® Mixing? - Resodyn Acoustic Mixers

Dec 30, 2020  Fortunately, a new and innovative technology, ResonantAcoustic® Mixing (RAM), solves many of the problems that plague traditional mixers. RAM combines the efficient power generation of resonance and the effects of sound energy to facilitate mixing – without the use of impellers or other mechanical means within a mixing vessel.

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Evaluation of Resonant Acoustic Mixing Performance ...

The resonant acoustic mixing (RAM) is a non-contact mixing technology , that induces a low-frequency acoustic field to facilitate mixing through mechanical resonance [17, 18]. This newly ...

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In-line and Real-time Monitoring of Resonant Acoustic ...

Run 1 – 4 for mixing process monitoring were prepared on the basis of the formulations in Table 2, and the mixing processes were monitored using the NIR method. Resonant acoustic mixing conditions The equipment used was a Resonant Acoustic LabRAM (Resodyn, MT), with the frequency fixed at 60 Hz. Table 2 shows each vibration force.

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Fernando J. Muzzio Rutgers University, Chemical ...

Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets. J.G. Osorio, K. Sowrirajan, F.J. Muzzio, Advanced Powder Technology 27 1141-1148 (2016). Enabling real time release testing by NIR prediction of dissolution of tablets made by Continuous Direct Compression (CDC). P.

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Evaluation of resonance acoustic mixing technology using ...

Evaluation of resonance acoustic mixing technology using ultra high performance concrete Aileen Vandenberga, Kay Willeb,⇑ a Civil and Environmental Engineering, University of Connecticut, 261 Glenbrook Road, Unit 3037, Storrs, CT 06269-3037, United States bDepartment of Civil and Environmental Engineering, University of Connecticut, United States ...

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© 2014 Juan Guillermo Osorio Caicedo ALL RIGHTS RESERVED

pharmaceutical ingredients (APIs). The work presented in this dissertation focuses on the macro- and micro-mixing characterization of a resonant acoustic mixer (RAM), and the micro-mixing dynamic characterization of bin-blending for pharmaceutical powders, with an

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Ball-free mechanochemistry: in situ real-time monitoring ...

monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing† Adam A. L. Michalchuk, *abc Karl S. Hope, ad Stuart R. Kennedy, a Maria V. Blanco, e Elena V. Boldyreva *cf and Colin R. Pulham *ab Resonant acoustic mixing (RAM) is a new technology designed for intensive mixing of powders that offers the capability to process

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‪Juan G. Osorio‬ - ‪Google Scholar‬

Effect of resonant acoustic mixing on pharmaceutical powder blends and tablets JG Osorio, K Sowrirajan, FJ Muzzio Advanced Powder Technology 27 (4), 1141-1148 , 2016

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Alternative Mixing Technologies for High-Energy, Solid ...

Apr 21, 2017  Resonance acoustic mixing (RAM) technology is a new approach to processing in which low-frequency, high-intensity vibrations are used in place of impeller blades to generate the shear field required to mix high-energy, solid materials. Also, RAM technology eliminates the need for cleaning the impellers at the end of each production run.

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(PDF) Resonant states in modulation-doped heterostructures ...

Therefore the resonance curve is rather asymmetric, since it cannot be continued below the lowest subband. The amplitude of – 83 – fDonor states in modulation-doped Si/SiGe heterostructures the resonance, as measured by d1 (EΣ∗u ), is furthermore very small as long as the resonance is close to the band bottom.

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Wikizero - Broadband acoustic resonance dissolution ...

Broadband acoustic resonance dissolution spectroscopy (also known as BARDS) is a technique developed in the late 2000s, which is used in analytical chemistry.It involves the analysis of the changes in sound frequency generated when a solute dissolves in a solvent, by harnessing the hot chocolate effect first described by Frank S. Crawford.. The technique is partly based on the solubility ...

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Environmental and Occupational Medicine - Janis Dundurs ...

Air has the following effects on the human health: • direct, components cause illnesses or poisoning; • indirect, functioning as a risk factor, i.e. decreases the activity of human immune system, increases the onset of various diseases; • distant effect, the cause of the disease can be diagnosed more than a few years later, e.g. cancer.

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Applying dry powder coatings: Using a resonant acoustic ...

The acoustic mixing has been previously used for liquid mixing (31,32), powder mixing (33,34), and dry coating of drugs and excipients (35)(36)(37) (38). In this process, low-frequency, high ...

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(657a) Resonant Acoustic (Vibratory) Powder Mixing ...

Resonant acoustic mixing is known to significantly reduce mixing time making it a good candidate for improving the efficiency of powder mixing processes. The blend uniformity of lactose and acetaminophen powders blended using the RAM is compared to mixing results obtained using a

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RESONANTACOUSTIC MIXING; UNIFORM DISTRIBUTION OF

The effect of the mix equipment and mixing parameters on the uniformity of the blended material is determined by analyzing the amount of acetaminophen in a number of samples at specific mix times.

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Macro and micro characterization of powder mixing processes

The work presented in this dissertation focuses on the macro- and micro-mixing characterization of a resonant acoustic mixer (RAM), and the micro-mixing dynamic characterization of bin-blending for pharmaceutical powders, with an emphasis on mixing cohesive APIs. First, the mixing performance of the RAM as a function of processing parameters ...

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Acoustic Mixing Patents - Resodyn Acoustic Mixers

Nano-suspension process - Merck Sharp Dohme Corp (2016) US Patent Number- 9,381,518. Pharmaceutical compositions that inhibit disproportionation - Merck Sharp Dohme Corp (2016) US Patent Number- 9,339,543. Preparing colorant dispersions using acoustic mixing - Xerox Corporation (2015) US Patent Number- 9,223,236.

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Basic Principles of Powder Mixing - Resodyn Acoustic Mixers

Mar 03, 2021  Powder mixing is common in companies across many industries, including those in the pharmaceutical, advanced materials, and chemical sectors. The mixing step is crucial to many processes with the primary objective to achieve uniform distribution of all ingredients. Powder mixing may seem simple, but is often complicated.

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Industries Served - Resodyn Acoustic Mixers

Jun 02, 2021  The number of industries using acoustic mixing is ever growing. Organizations around the globe are learning how ResonantAcoustic ® Mixing technology boosts efficiency and profitability, and enables new discoveries with its versatility and power. Learn how RAM mixing and processing technology is changing processing in your industry, take inspiration from how it's revolutionizing

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Traditional Mixing vs Acoustic Mixing - Resodyn Acoustic ...

Jan 27, 2021  Acoustic mixing uses sound energy to generate unique material movement and sound-induced interactions that swiftly result in optimal and uniform mixing. More specifically, RAM mixers generate and control rapid and relatively large-scale vertical motion to drive movement of the mixer’s resonator plate and thus within the mixing vessel itself.

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Verification of the mixing processes of the active ...

The resonant acoustic® mixing (RAM) technology is a blending method, and it has been reported that it has a unique mixing action for various samples. In this study, in order to apply the RAM method to the pharmaceutical blending process, optimization of the operating conditions of RAM (acceleration and frequency) was conducted by numerical ...

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Complete Cocrystal Formation during Resonant Acoustic Wet ...

Jan 01, 2020  The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules. Resonant acoustic wet granulation (RAG) was devised in an effort to complete theophylline–citric acid (THPCIT) cocrystal formation during the granulation process, thereby reducing the number of operations.

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Is ResonantAcoustic Mixing® (RAM) a Game Changer for ...

Mechanical dry particle coating on cohesive pharmaceutical powders for improving flowability - A review. Rahul ... Effect of aluminum nanoparticles on rheological behavior of HTPB-based composite rocket propellant ... Abstract This study presents an investigation on the mixing efficiency of Resonance Acoustic Mixing (RAM) Technology® using ...

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News Media - Resodyn Acoustic Mixers

Jun 02, 2021  Current Trends in Mixing Technology: 2021. June 2, 2021. From food and beverage production to fertilizer plants to pharmaceutical operations, mixing is a key... Read More. vamtam-theme-circle-post.

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RAM MIXER™ - PCCA

Resonant acoustic mixing ensures an even distribution of the active pharmaceutical ingredient (API) with repeatable results from mix to mix. It removes the human element from traditional mixing where potency results can be inconsistent depending on the pharmacist's or technician’s mixing techniques.

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Proper Orthogonal Decomposition Analysis and Dispersion ...

Mar 04, 2020  The investigation on the flow field and mixing characteristics of resonant sound mixing is of great significance for the dispersion mixing of superfine materials. In order to simulate the flow field and dispersion characteristics of resonant acoustic mixing, a gas-liquid-solid three-phase flow model based on the coupled level-set and volume-of-fluid (CLSVOF) and discrete particle model (DPM ...

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